Skip to main content

Needless Vaccination in Paediatric population age 12yr to 18yr by ZYCOV- D By DR BHARGAVI BADE

Cadila Healthcare Limited, India developed a candidate vaccine ZyCoV-D comprising of a DNA plasmid vector carrying the gene encoding the spike protein (S) of the SARS-CoV-2 virus. (S) protein, following immunization with three doses adminis- tered 28 days apart. Neutralizing antibody response was also demonstrated against wild type SARS-CoV-2 strain, which may play a substantial role in viral clearance and mitigation of human clinical disease. Implications of all the available evidence Many vaccine candi- dates are in rapid development, including recombinant-protein based vaccines, replicating or non-replicating viral vector- based vaccines, DNA vaccines, and mRNA vaccines (which mostly have focused on the spike glycoprotein or receptor binding domain), live attenuated vaccines, and inactivated virus vaccines. Our findings indicate that DNA vaccine is safe and immunogenic in healthy adults. ZyCoV-D® vaccination course consists of three separate doses of 0.2 ml each. ZyCoV-D® vaccination schedule consists of 3 separate doses of 2 mg each to be given at an interval of 28 days each (day 0, day 28 and day 56).
Each 2 mg dose consists of two shots of 0.1ml each given by needle free injector (Pharmajet Tropis device) via intradermal route at two separate sites (preferably deltoid region of both the arms). Special warnings and precautions for use Hypersensitivity As with all injectable vaccines, appropriate medical treatment and supervision should always be readily available in case of an anaphylactic event following the administration of the vaccine. Concurrent Illness As with other vaccines, administration of ZyCoV-D® should be postponed in individuals suffering from an acute severe febrile illness. However, the presence of a minor infection, such as cold, and/or low grade fever should not delay vaccination. Immunocompromised individuals It is not known whether individuals with impaired immune responsiveness, including individuals receiving immunosuppressant therapy, will elicit the same response as immunocompetent individuals to the vaccine regimen. Immunocompromised individuals may have relatively weaker immune response to the vaccine regimen. Common side effects Injection site redness Injection site pain Injection site itching Injection site swelling Fever Muscle Pain Headache Nausea Fatigue / Tiredness Diarrhea

Comments

Post a Comment

Popular posts from this blog

Painless covid booster Gencovacc om ( mRNA)

Why do ONE need a COVID booster? Q.1 I have already received two doses of COVID vaccine. The Omicron variants of Corona Virus are still causing COVID and impacting healthcare systems and IMMUNOCOMPROMISED and comorbid condition like asthma,diabetes,cancer and obesity . The Vaccines that were given earlier as 2 dose primary series were based on Wuhan strain and may not be highly effective against currently circulating Omicron strain and its variants. Q.2 Which age group is this vaccine indicated for? g older adults and adults with comorbidities. In India, NTAGI recommends Omicron booster for individuals over 60 years of age and all adults who are comorbid or with weak immunity (immunocompromised). The composition of mRNA vaccines can be modified quickly which helps in fighting the emerging variants. Q.6 Are mRNA vaccines available globally? Over 450 crore doses of mRNA vaccines have been distributed in over 180 countries, preventing COVID since 2020, Q.7 How is this vaccine ...
Post a Comment
Read more

Eye fitness criteria for pilots and Aviation aspirants

Aspirant pilots have anziety towards his glasses 2. The following ophthalmological conditions are disqualifying for initial issue medical examinations: (a) History/ evidence of recurrent keratitis (b) Keratoconus (c) Macular degeneration (d) Hereditary degeneration which interferes with visual acuity and/or visual fields (e) Retinitis Pigmentosa (f) Retinal Detachment (g) Retinal vascular disorders with exudates or neovascularisation (h) Optic neuritis and optic atrophy (i) Central Serous Retinopathy (j) Glaucoma (k) Any intraocular surgery (l) Manifest squint 3. students for initial issue medical examination having corneal / congenital lenticular opacities which are non-progressive and do not interfere with vision may be considered fit for flying duties. 4. Lattice Degeneration (LD) and retinal holes. LD of the retina is a common vitreo-retinal degeneration. High risk features in LD which may predispose to retinal detachment (RD) include extent of LD more than three clock hours, p...
Post a Comment
Read more

fitness criteria for aspiring pilots

Pilot Fitness: Meeting DGCA’s Physical Fitness Standards for Aspiring Pilots A pilot’s role requires both mental and physical endurance, which makes physical fitness a crucial component of their ability to fly safely. The Directorate General of Civil Aviation (DGCA) sets strict fitness standards for pilots. In this guide, we’ll walk you through the key fitness requirements for aspiring pilots, focusing on challenges like obesity, vision correction, and the need for overall health maintenance to meet DGCA standards. What Are DGCA’s Fitness Requirements for Pilots? The DGCA mandates several health and fitness criteria that every pilot must meet to ensure safe flying conditions. These standards focus on key areas such as weight (BMI), cardiovascular health, vision, and musculoskeletal fitness. Pilots must be capable of handling stressful conditions, long hours, and high altitudes. Managing Your BMI and Weight Control One of the critical fitness aspects for aspiring pilots is Body Mass ...
Post a Comment
Read more